Author's response to reviews Title: Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults Authors:
نویسندگان
چکیده
Felix Schreiner ([email protected]) Osman El-Maarri ([email protected]) Bettina Gohlke ([email protected]) Sonja Stutte ([email protected]) Nicole Nuesgen ([email protected]) Manuel Mattheisen ([email protected]) Rolf Fimmers ([email protected]) Peter Bartmann ([email protected]) Johannes Oldenburg ([email protected]) Joachim Woelfle ([email protected])
منابع مشابه
Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene.
Monozygotic (MZ) twin concordance for a range of psychiatric conditions is rarely 100%. It has been suggested that epigenetic factors, such as DNA methylation, may account for a proportion of the variation in behavioral traits observed between these genetically identical individuals. In this study we have quantitatively assessed the methylation status of two CpG sites in the promoter region of ...
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BACKGROUND The human endogenous retroviral family W, Env(C7), member 1 gene (HERVWE1) is thought to participate in trophoblast cell fusion, and its expression is diminished in the placentas of singleton intrauterine growth-retarded pregnancies. However, there is limited information about the role of HERVWE1 in discordant fetal growth in twins. This study was to compare HERVWE1 gene expression b...
متن کاملCOMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia.
OBJECTIVES In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia. METHODS The sample consisted of 85 monozygotic and 53 dizygotic twin pairs, of varying concordance for schizophrenia, and healthy control twins...
متن کاملAssociation study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran
Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association ...
متن کاملMultiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer.
Catechol-O-methyltransferase (COMT) plays an important role in estrogen-induced cancers because COMT inactivates catechol estrogens that have cancer-promoting activities. Two promoters control the expression of human COMT isoforms: membrane-bound COMT (MB-COMT) and soluble COMT (S-COMT). We hypothesize that inactivation of MB-COMT and S-COMT is important in understanding the pathogenesis of end...
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